KMID : 0043320010240050437
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Archives of Pharmacal Research 2001 Volume.24 No. 5 p.437 ~ p.440
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Effect of Eurycoma longifolia Jack on Laevator Ani Muscle in Both Uncastrated and Testosterone-Stimulated Castrated Intact Male Rats
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Ang Hooi-Hoon
Cheang Hung-Seong
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Abstract
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It has been reported that Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoreity as a symbol of man¡¯s ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities. As such, the effects of 200, 400 and 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack were studied on the laevator am muscle in both uncastrated and testosterone-stimulated castrated intact male rats after dosing them for 12 consecutive weeks. Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack significantly increased (p<0.05) the leavator am muscle to 58.561.22, 58.23 0.31, 60.21 0.86 and 62.35 0.98 mg/100 g body weight, respectively, when compared with the control (untreated) in the uncastrated intact male rats and 49.23 0.82, 52.23 0.36, 50.21 0.66 and 52.35 0.58 mg/100 g body weight, respectivety, when compared to control (untreated) in the testosterone-stimulated castrated intact male rats. Hence the proandrogenic effect as shown by this study further supported the traditional use of this plant as an aphrodisiac
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KEYWORD
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Eurycoma longifolia Jack, Laevator am muscle, Uucastrated, Testosterone-stimulated castrated, Intact male rats, Pro-androgenic
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